Tuesday, March 15, 2016

"Response prediction in chronic hepatitis C by assessment of IP-10 and IL28B-related single nucleotide polymorphisms"

Just a question regarding figure 3 and 4:
Why are the distribution of quite many of the individual data points in figure 3 so similar when comparing illustrations in especially A and D and B and E ?

In figure 4, the graphs looks very similar with similar breakpoints (compare blue and green graph in A, B and C, and compare red graph in A and B)

http://i.imgur.com/OTMm8Jb.png

Regarding Figure 3: The data are correct. Patients may carry more than one of the single nucleotide polymorphisms in proximity to IL28B evaluated in the study (i.e. rs12979860, rs12980275, and rs12980275). Thus values of the decline in HCV RNA in relation to the baseline IP-10 level from a patient shown in either A, B, or C (i.e. the genetic variants of rs12979860) may also appear in D, E, or F (i.e. the genetic variants of rs12980275), as well as in G, H, or I (i.e. the genetic variants of rs8099917).

Regarding Figure 4: The breakpoints in all curves are similar with the greatest decline in HCV RNA observed in proximity to the weekly interferon injections, e.g. between day 0 and 1, and between day 7 and 8.

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